Founded the Aero Corporation of California and Standard Airlines, which was later consolidated with Western Air Express to form Transcontinental & Western Air (TWA) in 1930.
Became president of TWA after his famous letter to aircraft manufacturers calling for the development of a safer, more efficient aircraft.
Set a commercial aircraft altitude record in 1929 of 22,680 feet.
Kept airmail contracts from being cancelled by making a record transcontinental flight of 13 hours, 4 minutes in the DC-1 in 1934, therefore proving that airlines were a proficient mode of transporting mail.
Took the lead in exploring high-speed, high-altitude, all-weather flying. This research led to the development of the Boeing 307 “Stratoliner”- the first fully pressurized passenger aircraft.
In 1944 TWA received the first of the new Lockheed 049 “Constellation” series, which Frye and Hughes piloted on a record-breaking flight across the country on April 17, 1944.
Formed The Frye Corporation in 1955 to develop a rugged tri-motored airplane for use in underdeveloped countries.